The opposite of "most self-dependent" could be described using a variety of antonyms, depending on the context. Some potential options might include "dependent," "needy," "reliant," or "subservient." These terms suggest a lack of independence or self-sufficiency, and instead imply a reliance on others for support or guidance. Conversely, the term "self-reliant" might also be considered an antonym for "most self-dependent," as it suggests a similar sense of strength and independence, albeit with a slightly different nuance. Ultimately, the precise antonym for "most self-dependent" will depend on the specific meaning and usage of the original term.