The phrase "the reply is in the negative" typically indicates that an answer or response has been given that is negative or unfavorable. There are several synonyms one could use to convey this same meaning, such as "the answer is no," "there's a rejection," "a negative response was given," or "the response was unfavorable." Additionally, one could use phrases like "the outcome was not what was hoped for," "there was a denial," or "the request was declined." Regardless of the specific wording used, the important thing is to clearly convey that the response given was not positive or affirmative.